Department of Neurosurgery, Maastricht University Medical Center
School for Mental Health and Neuroscience, Maastricht University
Yasin Temel is a neurosurgeon with a strong interest in translational Neuroscience. He received his MD degree in 2001 and his PhD degree in 2007, both at Maastricht University. He finished his Neurosurgery training in 2010. His clinical activities include general Neurosurgery, with special emphasis on Functional Neurosurgery and Skull Base surgery. His research activities are directly linked to these two topics. The first line of research focuses on improving existing neuromodulatory treatments and developing novel therapies for neurodegenerative disorders. The second line of research aims to develop biological markers predicting the disease course and surgical outcome of skull base tumors such as chordomas and vestibular schwannomas.
Stimulating deep brain structures for more than 25 years: what have we learned?
DBS is a fast emerging area of Translational Neuroscience. While the first indication for modern DBS was a patient with Parkinson’s in 1987, nowadays patients with severe psychiatric disorders and epilepsy are considered good candidates. The field is witnessing a broadening of indications. We have learned important lessons from experimental work. While the initial idea was that the mechanism of action of DBS was the induction of a depolarization block of local neurons, now a more complex multi-faceted mechanism is proposed. Some authors have even found evidence for a disease modifying effect in experimental approaches. In this lecture, I will highlight essentials of DBS from a translational perspective.