Department of Neurobiology, the Weizmann Institute of Science
Prof. Amiram Grinvald received his BSc (1968) and MSc (1970) from the Hebrew University studying Physics and Chemistry and a PhD (1974) from the Weizmann Institute studying spectroscopy and biophsics. He received training in Neurobiology at Hadassah School of Medicine and at Yale. Grinvald joined the faculty of the Weizmann Institute in 1978. His many prizes and honors include the Teva Prize (1985), Korber Europe Prize (2000) and the prestigious international Dan David Prize for Brain Research (2004). He is a member of the Israel Academy of Sciences and Humanities, the Neuroscience Institute in San Diego, California, , the American Association for the Advancement of Science, and an external member of the Max Planck Society.
Intrinsic optical imaging; from the bench to the clinics
In the neocortex, neurons with similar response properties are often clustered together in column-like structures, giving rise to what has become known as functional architecture.
Optical imaging of intrinsic signals in the neocortex reaches the striking detail of ~ 50µm, and, it has allowed to characterize the metabolic and haemodynamic responses induced by sensory-evoked neuronal activity. The precise neuronal origin of the hemodynamic responses measured by optical imaging, laser Doppler flowmetry, or fMRI will be reviewed. Recent results from voltage sensitive dye imaging, providing an extraordinary temporal resolution in addition to spatial resolution will be described.
Optical imaging proved to be a useful tool in functional studies of the retina providing early diagnosis of the prevalent retinal diseases. Retinal reflectance changes in the absence of photic stimulations, or in its presence, yield information obtained none invasively about red blood cell blood velocity, capillary images of richer information relative the gold standard FA (but without any contrast agent), qualitative oximerty, choroidal visualization and in response to photic stimulation, information is provided about metabolic processes underlying responses in the retina. Quantitative and qualitative images of these parameters are obtained using an FDA approved Retinal Function Imager (RFI).